Research grade

Oral Capsules

TB-500 Capsules

Synthetic Thymosin Beta-4 — all 43 amino acids with the LKKTETQ actin-binding motif Oral capsule format — 500 mcg per capsule, 30 capsules per bottle, no reconstitution Third-party lab tested · CAS 77591-33-4 For in vitro cell-migration and actin research only

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For laboratory research use only. Not for human or veterinary consumption. SKU TB500C.

Overview

Product details.

TB-500 Capsules — Thymosin Beta-4 (500 mcg)

Thymosin Beta-4 is one of the most conserved actin-regulating proteins in nature — present in nearly every mammalian cell type, from platelets to white blood cells to wound fluid. TB-500 is the synthetic form: all 43 amino acids, including the critical LKKTETQ motif at positions 17-23 that gives it high-affinity actin binding. Published research on this compound spans Nature, The FASEB Journal, and The Journal of Investigative Dermatology. This listing is the oral capsule presentation, delivering a precise 500 mcg per capsule for consistent per-capsule amounts across a research protocol.

Research-Grade Compounds

Manufactured to research-grade standards for laboratory research use only.

Discreet Shipping

Every order ships in plain, protective packaging.

In-House Fulfillment

Orders are inspected, packed, and shipped directly by the Heritage Labs team.

An oral capsule format

The peptides in this category are most often supplied as lyophilized powder for reconstitution. This listing supplies TB-500 as a pre-measured oral capsule instead — each capsule holds a fixed 500 mcg, so researchers can standardize per-capsule quantities without reconstitution, vials, or measuring. It is the same synthetic 43-amino-acid Thymosin Beta-4 sequence as the vial presentation; only the delivery format differs.

Specifications

Full Sequence	Ac-Ser-Asp-Lys-Pro-Asp-Met-Ala-Glu-Ile-Glu-Lys-Phe-Asp-Lys-Ser-Lys-Leu-Lys-Lys-Thr-Glu-Thr-Gln-Glu-Lys-Asn-Pro-Leu-Pro-Ser-Lys-Glu-Thr-Ile-Glu-Gln-Glu-Lys-Gln-Ala-Gly-Glu-Ser
Active Region	LKKTETQ (amino acids 17-23)
Molecular Formula	C₂₁₂H₃₅₀N₅₆O₇₈S
Molecular Weight	4963.44 g/mol
CAS Number	77591-33-4
PubChem CID	16132042
Form	Oral capsule
Strength	500 mcg per capsule
Format	30 capsules per bottle

The research record

Malinda et al. reported a 41% increase in re-epithelialization within 4 days in full-thickness dermal wound models, concluding that “Tβ4 is a potent wound healing factor with multiple activities” (J Investigative Dermatology, 1999; PubMed 10469335).

Bock-Marquette et al. published findings in Nature showing enhanced cardiomyocyte migration and survival through integrin-linked kinase (ILK) and Akt signaling activation in myocardial infarction models (Nature, 2004; PubMed 15565145).

Philp et al. characterized angiogenesis and directional cell migration in both normal and aged rodent models through endothelial tube formation and ECM remodeling (Annals NYAS, 2004; PubMed 15037013).

Goldstein et al. reviewed NF-κB signaling modulation, pro-inflammatory cytokine reduction, and decreased inflammatory cell infiltration in tissue models (Expert Opinion on Biological Therapy, 2012; PubMed 22074294).

TB-500 vs BPC-157

Different mechanisms for different systems. TB-500 research centers on actin regulation, cell migration, blood vessel formation, and cardiac tissue. BPC-157 research centers on gastrointestinal integrity, connective tissue, and nitric oxide pathways. Published protocols regard them as complementary, not interchangeable. Heritage Labs USA carries both in capsule and vial formats.

Research applications

Cell migration and wound closure assays
Actin polymerization dynamics and G-actin/F-actin equilibrium
Angiogenesis pathway screening
ECM remodeling and collagen expression
Inflammatory signaling profiling
Cardiac cell survival and ILK activation

Frequently paired with

TB-500 10mg — Same peptide, 10mg per vial for reconstitution.
BPC-157 Capsules — Complementary connective-tissue research, same capsule format.
GHK-Cu Capsules — ECM remodeling studies.

Quality and testing

Third-party tested by an independent lab for identity, density and purity. Certificates of analysis are published on the product page and in the COA portal. Manufactured to research-grade standards and shipped in protective packaging.

Storage

Sealed capsules: Store in a cool, dry place away from light and moisture.
Handling: Keep the bottle tightly closed; avoid heat and humidity.
No reconstitution required.

References

Malinda KM, et al. J Investigative Dermatology. 1999;113(3):364-368. PubMed 10469335
Bock-Marquette I, et al. Nature. 2004;432(7016):466-472. PubMed 15565145
Philp D, et al. Annals NYAS. 2004;1012:44-52. PubMed 15037013
Goldstein AL, et al. Expert Opinion on Biological Therapy. 2012;12(1):37-51. PubMed 22074294

Third-party lab tested · For research use only. Not for human consumption.

For laboratory research use only. Not for human or veterinary use. This product is not a drug or supplement and is not intended to diagnose, treat, cure, or prevent any disease.

FDA Disclaimer. All products are for research use only (RUO) as defined by the FDA — not for diagnostic, human, or veterinary use. These products have not been evaluated and have not been approved by the U.S. Food and Drug Administration and are not intended to diagnose, treat, cure, or prevent any disease.

Heritage Labs is a chemical supplier providing products strictly for laboratory research, analytical, and in-vitro purposes; it is not a compounding pharmacy or compounding facility under Section 503A, nor an outsourcing facility under Section 503B, of the Federal Food, Drug, and Cosmetic Act.