Semax 5mg

ACTH(4-10) fragment analog heptapeptide (Met-Glu-His-Phe-Pro-Gly-Pro) with PGP stabilization 100+ published studies — retains neurotrophic activity without steroidogenic effects Research-grade · CAS 80714-61-0 For in vitro neuropeptide research only

$29.99 In stock

Research-Grade CompoundsManufactured to research-grade standards for laboratory research use only.

Discreet ShippingEvery order ships in plain, protective packaging.

In-House FulfillmentOrders are inspected, packed, and shipped directly by the Heritage Labs team.

Same-day dispatch on orders before 12:00 PM ET, Mon–Fri. Discreet, plain packaging.

In-House Fulfillment Orders are inspected, packed, and shipped directly by the Heritage Labs team.

View this compound’s Certificate of Analysis →

SSL 256-bit Secure Checkout

For laboratory research use only. Not for human or veterinary consumption. SKU XA5.

Overview

Product details.

Semax 5mg — ACTH(4-10) Analog

Take the 4-10 fragment of adrenocorticotropic hormone. Add a Pro-Gly-Pro tail for metabolic stability. The result is Semax — a heptapeptide developed at the Institute of Molecular Genetics of the Russian Academy of Sciences that retains neurotrophic activity from the parent hormone while completely shedding its adrenal steroidogenic effects. Over 100 published papers have examined this compound in the context of neurotrophic factor expression, neuropeptide signaling, and CNS pathway modulation.

Research-Grade Compounds

Manufactured to research-grade standards for laboratory research use only.

Discreet Shipping

Every order ships in plain, protective packaging.

In-House Fulfillment

Orders are inspected, packed, and shipped directly by the Heritage Labs team.

Specifications

Sequence	Met-Glu-His-Phe-Pro-Gly-Pro (ACTH 4-10 + PGP)
Amino Acids	7
Molecular Formula	C₃₉H₆₃N₁₁O₁₀
Molecular Weight	813.97 g/mol
CAS Number	80714-61-0
Form	Lyophilized powder
Quantity	5mg per vial

Neurotrophic factor effects

Research has documented Semax’s influence on BDNF, NGF, and GDNF expression in neuronal cultures. The interesting part is what it does not do: unlike the full ACTH molecule, the 4-10 fragment does not drive adrenal steroid production. The neurotrophic activity and steroidogenic activity occupy different regions of the parent peptide, and Semax retains only the former.

Additional research areas

Published studies have examined dopaminergic and serotonergic system modulation, oxidative stress markers in neuronal models, and the pharmacokinetic properties of the Pro-Gly-Pro stability extension — a design shared with the related peptide Selank (tuftsin + PGP).

Frequently paired with

Selank 5mg — Both share the PGP stabilization motif but derive from different parent sequences.

Quality and testing

Every Heritage Labs compound is manufactured to research-grade standards and shipped in protective packaging.

Storage

Lyophilized: -20°C
Reconstituted: 2-8°C, use within 30 days

For laboratory research use only. Not for human or veterinary use.

For laboratory research use only. Not for human or veterinary use. This product is not a drug or supplement and is not intended to diagnose, treat, cure, or prevent any disease.

FDA DISCLAIMER: All products are intended for research use only as defined by the FDA. Not for use in diagnostic procedures, human use, or veterinary use. Products have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease. All products sold by Heritage Labs are intended strictly for laboratory research, analytical, or in-vitro purposes only. Heritage Labs operates as a chemical supplier and is not a compounding pharmacy or chemical compounding facility as defined under Section 503A of the Federal Food, Drug, and Cosmetic Act. Additionally, Heritage Labs is not classified as an outsourcing facility under Section 503B of the same Act. The statements on this website have not been evaluated by the U.S. Food and Drug Administration. Our products are not intended to diagnose, treat, cure, or prevent any disease.