Melanotan 2 10mg

Synthetic α-MSH analog — cyclic heptapeptide · 10mg research quantity MC1R / MC4R melanocortin receptor agonist (parent compound of PT-141 / bremelanotide) Research-grade · CAS 121062-08-6 For in vitro melanocortin receptor and pigmentation research only

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For laboratory research use only. Not for human or veterinary consumption. SKU MT2.

Overview

Product details.

Melanotan 2 10mg — MT-II

Melanotan II — MT-2 — is the parent compound from which PT-141 (bremelanotide) was later derived. It is a cyclic seven-amino-acid analog of the endogenous neuropeptide α-melanocyte-stimulating hormone (α-MSH), engineered in the late 1980s at the University of Arizona to give the melanocortin receptor family a more tractable research probe: greater potency than the native hormone, broader subtype engagement than later derivatives, and a degradation profile slow enough to support meaningful experimental observation windows. Native α-MSH binds across all five melanocortin receptor subtypes (MC1R through MC5R) with moderate affinity and is cleaved by serum proteases within minutes. MT-2 was synthesized to overcome both limitations — it binds MC1R and MC4R with high potency, retains measurable activity at MC3R and MC5R, and its cyclic backbone with D-phenylalanine substitution resists enzymatic cleavage long enough for in vitro and ex vivo work to capture downstream signaling cleanly.

Research-Grade Compounds

Manufactured to research-grade standards for laboratory research use only.

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Specifications

Sequence	Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH₂
Molecular Formula	C₅₀H₆₉N₁₅O₉
Molecular Weight	1024.18 g/mol
CAS Number	121062-08-6
Classification	Non-selective MC1R / MC4R melanocortin receptor agonist
Form	Lyophilized powder
Quantity	10mg per vial

Melanocortin receptor pharmacology

The melanocortin family covers a spread of physiological signaling that runs from cutaneous pigment biology to central appetite regulation, energy expenditure, and inflammatory response modulation. MT-2 was synthesized to enable cleaner experimental access to these pathways by overcoming the two main limitations of α-MSH itself: poor pharmacokinetic stability and a flat affinity profile across all five MC receptor subtypes. MC1R, expressed predominantly on melanocytes, is the receptor most associated with eumelanin synthesis and UV-independent melanogenesis research. MC4R, expressed throughout the hypothalamus, has been the dominant focus of energy-homeostasis and feeding-behavior studies. MT-2’s potency at both subtypes makes it a useful single-compound model for parallel investigation of dermatological and central-nervous-system melanocortin signaling within the same study design.

Relationship to PT-141

Removing the C-terminal amide from MT-2 yields bremelanotide (PT-141), which shifts the receptor selectivity profile toward MC3R/MC4R while substantially reducing MC1R engagement. Investigators interested in dissecting MC1R-dominant versus MC3R/MC4R-dominant signaling commonly pair these two compounds — MT-2 as the broader-spectrum probe, PT-141 as the central-nervous-system-biased counterpart — to attribute observed effects to specific receptor subtypes within the same experimental framework.

Handling and reconstitution

Supplied as lyophilized powder. Reconstitute with bacteriostatic water for in vitro studies; store reconstituted material at 2–8°C and use within published peptide stability windows. Long-term storage of sealed lyophilized vials at –20°C preserves potency for documented timeframes. For laboratory research use only. Not for human or veterinary use. Not for diagnostic or therapeutic application.

For laboratory research use only. Not for human or veterinary use. This product is not a drug or supplement and is not intended to diagnose, treat, cure, or prevent any disease.

FDA Disclaimer. All products are for research use only (RUO) as defined by the FDA — not for diagnostic, human, or veterinary use. These products have not been evaluated and have not been approved by the U.S. Food and Drug Administration and are not intended to diagnose, treat, cure, or prevent any disease.

Heritage Labs is a chemical supplier providing products strictly for laboratory research, analytical, and in-vitro purposes; it is not a compounding pharmacy or compounding facility under Section 503A, nor an outsourcing facility under Section 503B, of the Federal Food, Drug, and Cosmetic Act.