GHK-CU 50mg
Copper Tripeptide-1 (Gly-His-Lys:Cu²⁺) — naturally occurring copper-peptide complex Over 150 published studies in dermatological and biochemical research Research-grade · Copper content verified via ICP-MS For in vitro ECM remodeling research only
For laboratory research use only. Not for human or veterinary consumption. SKU CU50.
Product details.
A molecule that programs genes
The Broad Institute’s Connectivity Map database revealed something striking: GHK-Cu affects the expression of roughly 4,048 human genes, approximately 6% of the genome. The pattern is consistent — upregulation of collagen, growth factors, integrins, elastin, decorin, and glycosaminoglycans, alongside downregulation of inflammatory mediators and excess metalloproteinases (Pickart & Margolina, Int J Mol Sci, 2018; PMC6073405).
Plasma levels tell their own story: roughly 200 ng/mL at age 20, dropping to about 80 ng/mL by age 60. The copper(II) ion is not just structural scaffolding — it is functionally active in roughly 30 copper-dependent enzyme systems.
Specifications
| Sequence | Gly-His-Lys:Cu²⁺ |
| Molecular Formula | C14H24CuN6O4 |
| Molecular Weight | 403.92 g/mol |
| CAS Number (GHK) | 49557-75-7 |
| CAS Number (GHK-Cu) | 89030-95-5 |
| Form | Lyophilized powder |
| Appearance | Blue to blue-purple powder |
| Solubility | Soluble in water |
| Quantity | 50mg per vial |
Research areas
Extracellular matrix remodeling
Pickart’s original work in rat wound models established the foundation — GHK-Cu influences collagen synthesis, decorin production, and glycosaminoglycan expression in fibroblast cultures (Nature, 1980; PubMed 7453802).
MMP regulation
Research has examined GHK-Cu’s effects on MMP-2, MMP-9, and TIMP balance — the metalloproteinase system that governs ECM turnover and remodeling.
Antioxidant interactions
Flow cytometry and ESR spin-trapping studies have characterized interactions with SOD activity, glutathione peroxidase pathways, and hydroxyl/peroxyl radical species.
Anti-inflammatory pathways
Preclinical work in cigarette smoke-induced lung inflammation models documented NF-κB pathway modulation and Nrf2 activation effects on inflammatory mediator expression (Pickart & Margolina, 2018).
GHK-Cu vs BPC-157
Different compounds, different mechanisms. GHK-Cu works through copper-dependent enzymatic pathways and gene expression modulation. BPC-157 works through connective tissue models and nitric oxide signaling. Heritage Labs USA carries both individually and together in the Glow 50/10/10 blend (GHK-Cu + BPC-157 + TB-500).
Research applications
- Peptide-metal complex characterization via LC-MS
- Fibroblast and keratinocyte cell culture studies
- ECM remodeling and collagen expression analysis
- Copper-dependent enzyme pathway research
- Gene expression profiling and Connectivity Map analysis
- Antioxidant and anti-inflammatory pathway screening
Quality and testing
Every Heritage Labs compound is manufactured to research-grade standards and shipped in protective packaging.
Storage
- Lyophilized: -20°C for long-term stability
- Reconstituted: 2-8°C, use within 30 days
- Protection: Shield from light and moisture
Frequently paired with
- BPC-157 5mg — Also available in Glow 50/10/10.
- Epithalon 10mg — Telomerase-focused research.
- SNAP-8 10mg — SNARE complex studies.
References
- Pickart L, et al. “Growth-modulating plasma tripeptide may function by facilitating copper uptake into cells.” Nature. 1980;288(5792):715-717. PubMed 7453802
- Pickart L, Margolina A. “Regenerative and Protective Actions of the GHK-Cu Peptide in the Light of the New Gene Data.” Int J Mol Sci. 2018;19(7):1987. PMC6073405
- Park JR, et al. “The tri-peptide GHK-Cu complex ameliorates lipopolysaccharide-induced acute lung injury in mice.” Oncotarget. 2016;7(36):58405-58417.
For laboratory research use only. Not for human or veterinary use. Not a drug, food, or cosmetic.
