LL-37 5mg

Human cathelicidin antimicrobial peptide — 37 amino acids from the hCAP-18 C-terminal domain The only cathelicidin-derived antimicrobial peptide identified in humans Research-grade · CAS 154947-66-7 For in vitro antimicrobial and innate immunity research only

$59.99 $39.99 In stock

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For laboratory research use only. Not for human or veterinary consumption. SKU 375.

Overview

Product details.

LL-37 5mg — Human Cathelicidin

Humans have exactly one cathelicidin-derived antimicrobial peptide. This is it. LL-37 is the 37-amino-acid C-terminal fragment of hCAP-18 (human Cationic Antimicrobial Protein-18), and it turns out to be far more than just an antibiotic — it is a chemotactic agent, a TLR modulator, an angiogenesis pathway participant, and a biofilm disruptor. The research literature on LL-37 spans innate immunity, host defense, wound healing, and antimicrobial resistance.

Research-Grade Compounds

Manufactured to research-grade standards for laboratory research use only.

Discreet Shipping

Every order ships in plain, protective packaging.

In-House Fulfillment

Orders are inspected, packed, and shipped directly by the Heritage Labs team.

Specifications

Amino Acids	37
Parent Protein	hCAP-18
Molecular Formula	C₂₀₅H₃₄₀N₆₀O₅₃
Molecular Weight	4493.33 g/mol
CAS Number	154947-66-7
Structure	Amphipathic alpha-helix
Form	Lyophilized powder
Quantity	5mg per vial

Mechanism of action

The amphipathic alpha-helical structure is the key. One face of the helix is hydrophobic, the other hydrophilic. This lets LL-37 interact with the negatively charged phospholipids in bacterial membranes, leading to permeabilization. MIC studies have characterized activity against panels of gram-positive and gram-negative organisms. But the antimicrobial activity is only part of the story.

Beyond killing bacteria

Published research documents LL-37 as a chemotactic agent that recruits neutrophils, monocytes, and T cells through FPRL1 receptor interactions. It modulates TLR4 inflammatory signaling. It participates in VEGF-mediated angiogenesis and EGFR transactivation in epithelial models. And at sub-MIC concentrations, it disrupts bacterial biofilms by interfering with matrix components and quorum sensing.

Frequently paired with

BPC-157 5mg — Immune and tissue recovery research.

Quality and testing

Every Heritage Labs compound is manufactured to research-grade standards and shipped in protective packaging.

Storage

Lyophilized: -20°C
Reconstituted: 2-8°C, use within 30 days

For laboratory research use only. Not for human or veterinary use.

For laboratory research use only. Not for human or veterinary use. This product is not a drug or supplement and is not intended to diagnose, treat, cure, or prevent any disease.

FDA Disclaimer. All products are for research use only (RUO) as defined by the FDA — not for diagnostic, human, or veterinary use. These products have not been evaluated and have not been approved by the U.S. Food and Drug Administration and are not intended to diagnose, treat, cure, or prevent any disease.

Heritage Labs is a chemical supplier providing products strictly for laboratory research, analytical, and in-vitro purposes; it is not a compounding pharmacy or compounding facility under Section 503A, nor an outsourcing facility under Section 503B, of the Federal Food, Drug, and Cosmetic Act.