LL-37 5mg

Human cathelicidin antimicrobial peptide — 37 amino acids from the hCAP-18 C-terminal domain The only cathelicidin-derived antimicrobial peptide identified in humans Research-grade · CAS 154947-66-7 For in vitro antimicrobial and innate immunity research only

$59.99 In stock

Research-Grade CompoundsManufactured to research-grade standards for laboratory research use only.

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For laboratory research use only. Not for human or veterinary consumption. SKU 375.

Overview

Product details.

LL-37 5mg — Human Cathelicidin

Humans have exactly one cathelicidin-derived antimicrobial peptide. This is it. LL-37 is the 37-amino-acid C-terminal fragment of hCAP-18 (human Cationic Antimicrobial Protein-18), and it turns out to be far more than just an antibiotic — it is a chemotactic agent, a TLR modulator, an angiogenesis pathway participant, and a biofilm disruptor. The research literature on LL-37 spans innate immunity, host defense, wound healing, and antimicrobial resistance.

Research-Grade Compounds

Manufactured to research-grade standards for laboratory research use only.

Discreet Shipping

Every order ships in plain, protective packaging.

In-House Fulfillment

Orders are inspected, packed, and shipped directly by the Heritage Labs team.

Specifications

Amino Acids	37
Parent Protein	hCAP-18
Molecular Formula	C₂₀₅H₃₄₀N₆₀O₅₃
Molecular Weight	4493.33 g/mol
CAS Number	154947-66-7
Structure	Amphipathic alpha-helix
Form	Lyophilized powder
Quantity	5mg per vial

Mechanism of action

The amphipathic alpha-helical structure is the key. One face of the helix is hydrophobic, the other hydrophilic. This lets LL-37 interact with the negatively charged phospholipids in bacterial membranes, leading to permeabilization. MIC studies have characterized activity against panels of gram-positive and gram-negative organisms. But the antimicrobial activity is only part of the story.

Beyond killing bacteria

Published research documents LL-37 as a chemotactic agent that recruits neutrophils, monocytes, and T cells through FPRL1 receptor interactions. It modulates TLR4 inflammatory signaling. It participates in VEGF-mediated angiogenesis and EGFR transactivation in epithelial models. And at sub-MIC concentrations, it disrupts bacterial biofilms by interfering with matrix components and quorum sensing.

Frequently paired with

BPC-157 5mg — Immune and tissue recovery research.

Quality and testing

Every Heritage Labs compound is manufactured to research-grade standards and shipped in protective packaging.

Storage

Lyophilized: -20°C
Reconstituted: 2-8°C, use within 30 days

For laboratory research use only. Not for human or veterinary use.

For laboratory research use only. Not for human or veterinary use. This product is not a drug or supplement and is not intended to diagnose, treat, cure, or prevent any disease.

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