Research grade

Research Peptide

IGF-1 LR3 1mg

Synthetic analog of human Insulin-Like Growth Factor-1 (IGF-1) Contains an arginine substitution at position 3 and an extended chain Research-grade Supplied as a lyophilized powder for laboratory research

$75.99 In stock

Research-Grade CompoundsManufactured to research-grade standards for laboratory research use only.

Discreet ShippingEvery order ships in plain, protective packaging.

In-House FulfillmentOrders are inspected, packed, and shipped directly by the Heritage Labs team.

Same-day dispatch on orders before 12:00 PM ET, Mon–Fri. Discreet, plain packaging.

In-House Fulfillment Orders are inspected, packed, and shipped directly by the Heritage Labs team.

View Certificates of Analysis →

SSL 256-bit Secure Checkout

For laboratory research use only. Not for human or veterinary consumption. SKU IG1.

Overview

Product details.

IGF-1 LR3 1mg — Long R3 Insulin-Like Growth Factor-1

IGF-1 LR3 is an 83-amino-acid analog of human insulin-like growth factor-1, engineered for the research setting. It carries the native 70-residue IGF-1 sequence with arginine substituted for glutamic acid at position 3, plus a 13-residue N-terminal extension — modifications that sharply reduce its affinity for the IGF-binding proteins that normally sequester circulating IGF-1 within minutes. The result is an analog that stays free and receptor-available for roughly a day rather than minutes, making it one of the most widely used tools for studying sustained IGF-axis signaling.

Research-Grade Compounds

Manufactured to research-grade standards for laboratory research use only.

Discreet Shipping

Every order ships in plain, protective packaging.

In-House Fulfillment

Orders are inspected, packed, and shipped directly by the Heritage Labs team.

Why the “Long R3” modification matters

In circulation, native IGF-1 is almost entirely bound by IGFBP-1 through IGFBP-6, leaving only a small free fraction available to the receptor. The Arg3 substitution weakens IGFBP binding while the N-terminal extension stabilizes the molecule, so Long R3 IGF-1 remains free far longer than native IGF-1. This property was first exploited in mammalian cell-culture research, where Long R3 IGF-1 became a standard supplement for sustaining the viability and productivity of cultured cells in reduced-serum media.

Specifications

Analog	83-residue IGF-1 analog (Arg3 substitution + 13-residue N-terminal extension)
Molecular Weight	~9111 g/mol
CAS Number	946870-92-4
Molecular Purity	See COA
Form	Lyophilized powder
Reconstitution	Bacteriostatic (BAC) water
Storage	Cool, dry, away from direct light
Quantity	1mg per vial

Research areas

IGF-1 receptor signaling

Studied for activation of the IGF-1 receptor and the downstream PI3K/Akt and MAPK cascades that govern cellular growth, proliferation, and survival.

Cell-culture research

A standard supplement in serum-free and reduced-serum mammalian cell culture, studied for its ability to sustain cell viability and product yield.

Protein-synthesis models

Investigated in skeletal-muscle and connective-tissue models for its role in protein-synthesis signaling and cellular hypertrophy and hyperplasia pathways.

Metabolic research

Examined for cross-talk with insulin signaling and glucose-uptake pathways in metabolic research models.

Research applications

Studied in IGF-1 receptor and PI3K/Akt signaling research
Used as a supplement in mammalian cell-culture models
Relevant to protein-synthesis and tissue-growth pathway research
Investigated in metabolic and nutrient-partitioning models
Used to study sustained IGF-axis activation versus native IGF-1

For research use only. Not for human consumption.

For laboratory research use only. Not for human or veterinary use. This product is not a drug or supplement and is not intended to diagnose, treat, cure, or prevent any disease.

FDA DISCLAIMER: All products are intended for research use only as defined by the FDA. Not for use in diagnostic procedures, human use, or veterinary use. Products have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease. All products sold by Heritage Labs are intended strictly for laboratory research, analytical, or in-vitro purposes only. Heritage Labs operates as a chemical supplier and is not a compounding pharmacy or chemical compounding facility as defined under Section 503A of the Federal Food, Drug, and Cosmetic Act. Additionally, Heritage Labs is not classified as an outsourcing facility under Section 503B of the same Act. The statements on this website have not been evaluated by the U.S. Food and Drug Administration. Our products are not intended to diagnose, treat, cure, or prevent any disease.