Research grade

COA available

Research Peptide

CJC 1295 5mg

Modified GRF(1-29) — GHRH analog with four amino acid substitutions for enhanced stability 30 amino acids · No Drug Affinity Complex (DAC) — shorter half-life, pulsatile release profile Research-grade · CAS 863288-34-0 For in vitro GHRH receptor research only

$39.99 In stock

Research-Grade CompoundsManufactured to research-grade standards for laboratory research use only.

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In-House Fulfillment Orders are inspected, packed, and shipped directly by the Heritage Labs team.

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For laboratory research use only. Not for human or veterinary consumption. SKU CND5.

Overview

Product details.

CJC-1295 (No DAC) 5mg — Modified GRF 1-29

Native GHRH disintegrates in about seven minutes. DPP-IV enzymes clip it apart almost as fast as it can signal. CJC-1295 (No DAC) is the engineered answer — the same 1-29 amino acid GHRH fragment, but with four strategic substitutions at positions 2, 8, 15, and 27 that make it resistant to enzymatic degradation. The result: a half-life of 30 minutes to 2 hours instead of 7 minutes, without the sustained multi-day elevation that comes with DAC-modified variants.

Research-Grade Compounds

Manufactured to research-grade standards for laboratory research use only.

Discreet Shipping

Every order ships in plain, protective packaging.

In-House Fulfillment

Orders are inspected, packed, and shipped directly by the Heritage Labs team.

Specifications

Sequence	Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg-NH₂
Amino Acids	30
Molecular Formula	C₁₅₂H₂₅₂N₄₄O₄₂
Molecular Weight	3367.88 g/mol
CAS Number	863288-34-0
Form	Lyophilized powder
Quantity	5mg per vial

Mechanism

CJC-1295 binds GHRH receptors on pituitary somatotrophs, triggering adenylate cyclase, cAMP accumulation, PKA phosphorylation, and growth hormone vesicle release. The non-DAC form preserves pulsatile GH secretion patterns — closer to what endogenous GHRH produces — while the DAC version creates sustained, multi-day elevation. Published clinical data documents GH increases of 70-107% with IGF-1 elevations around 28% over 16-week observation periods (Khorram et al., JCEM, 1997; PubMed 9141541).

No DAC vs with DAC

The Drug Affinity Complex is a maleimidopropionic acid derivative that covalently binds serum albumin. With it: half-life jumps to 6-8 days, GH stays elevated constantly. Without it: half-life stays at 30 minutes to 2 hours, GH pulses naturally. Different tools for different research questions. Both available from Heritage Labs USA.

CJC-1295 + Ipamorelin

These two target different arms of the GH axis — GHRH receptor vs GHS-R (ghrelin receptor). Preclinical protocols routinely pair them to study dual-pathway somatotroph activation. The CJC-IPA blend combines both in a single vial.

Research applications

GHRH receptor binding kinetics and profiling
Peptide stability analysis under buffered conditions
Comparative GHRH analog studies (vs Sermorelin, Tesamorelin)
GH pulsatility and secretion pattern research
Dual-pathway studies when paired with GHS-R agonists

Frequently paired with

Ipamorelin 5mg — Also available as CJC-IPA Blend.
AOD-9604 5mg — Body composition research.

Quality and testing

Every Heritage Labs compound is manufactured to research-grade standards and shipped in protective packaging.

Storage

Lyophilized: -20°C
Reconstituted: 2-8°C, use within 30 days
Protection: Shield from light and moisture; avoid freeze-thaw cycles

References

Clark RG, Robinson ICAF. Nature. 1985;314(6008):281-283. PubMed 2858818
Khorram O, et al. J Clin Endocrinol Metab. 1997;82(5):1472-1479. PubMed 9141541
Martin B, et al. Neuromolecular Medicine. 2005;7(1-2):3-36.
Sinha DK, et al. Transl Androl Urol. 2020;9(Suppl 2):S149-S159. PMC7108996

For laboratory research use only. Not for human or veterinary use.

For laboratory research use only. Not for human or veterinary use. This product is not a drug or supplement and is not intended to diagnose, treat, cure, or prevent any disease.

FDA DISCLAIMER: All products are intended for research use only as defined by the FDA. Not for use in diagnostic procedures, human use, or veterinary use. Products have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease. All products sold by Heritage Labs are intended strictly for laboratory research, analytical, or in-vitro purposes only. Heritage Labs operates as a chemical supplier and is not a compounding pharmacy or chemical compounding facility as defined under Section 503A of the Federal Food, Drug, and Cosmetic Act. Additionally, Heritage Labs is not classified as an outsourcing facility under Section 503B of the same Act. The statements on this website have not been evaluated by the U.S. Food and Drug Administration. Our products are not intended to diagnose, treat, cure, or prevent any disease.